In 1981, wright identified it, owing to its different histology and relatively low recurrence rate, as orthokeratinized variant of odontogenic keratocyst. Nov 18, 2019 orthokeratinized odontogenic cyst ooc is a relatively rare lesion of the jaws, mainly located in the posterior segment of the mandible. Recurrence challenge in odontogenic keratocyst variants, two. Due to its different histopathology and reduced likelihood to recur, wright held it to be distinct from the parakeratotic type. Orthokeratinized odontogenic cyst ooc has been considered as a type of odontogenic keratocyst okc. Orthokeratinized odontogenic cyst ooc is an odontogenic cyst was initially termed as the uncommon orthokeratinized type of odontogenic keratocyst by the. Pdf synchronous ameloblastoma and orthokeratinized. The orthokeratinized odontogenic cyst ooc is a rare developmental odontogenic cyst that has been considered as a variant of the keratocystic odontogenic tumor until wright 1981 defined it as a. Ooc differs in many aspects from developmental odontogenic cysts, especially dentigerous cyst and okcs.
The cysts of the present series were all solitary lesions, occurred mostly in young male patients, and showed a predilection for the posterior mandible areas. A rare case report of orthokeratinized odontogenic. Clinically, it presents no tendency to relapse due to low local aggressiveness, and is not associated with the nevoid basal cell carcinoma syndrome nbccs. Squamous cell carcinoma emerging in an orthokeratinized. A clinical diagnosis of bilateral dentigerous cyst dc was rended. Such lesions were originally called orthokeratinised variant of okc.
A dentigerous cyst is one which encloses the crown of an unerupted. Okc represent a more aggressive form of odontogenic cyst. To investigate the clinicopathological features and behavior of a group of jaw cysts with a solely orthokeratinized lining epithelium. The orthokeratinized odontogenic cyst is a relatively rare developmental odontogenic cyst of the jaws that occurs predominantly in males between the third and fourth decades.
These cysts have been considered a distinct entity from odontogenic keratocysts. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts. It is epithelial in origin and arises from the cell rests of the dental lamina. They were originally believed to be part of the spectrum of odontogenic keratocyst, but are now considered to be a distinct entity. It is suggested that this cyst be called odontogenic keratocyst, orthokeratinized variant. The histopathological examination showed bilateral orthokeratinized odontogenic cyst.
Introduction it has long been documented and established that in addition to odontogenic keratocyst okc, the majority of odontogenic cysts produce orthokeratin. Orthokeratinized odontogenic cyse developmental odontogenic cysts characterised by an orthokeratinized strati. The orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst relatively rare, arising from the cell rests of the dental lamina. According to the 2005 world health organizations classification, orthokeratinized odontogenic cyst is not a part of the keratocystic odontogenic tumor spectrum. Odontogenic keratocyst was des ignated as keratocystic odontogenic tumor kcot in the new world health organization classification and ooc should be. Odontogenic cysts oc are epitheliumlined structures that appear in the toothbearing areas of both jaws and are considered uncommon in domestic animals.
Pdf orthokeratinized odontogenic cyst researchgate. Odontogenic keratocyst was designated as keratocystic odontogenic tumor kcot in the new world health organization classification and ooc should be distinguished from kcot for differences in. Followup of twentyfour patients revealed only one recurrence. There were no multiple cysts, and one case was recur rent. The odontogenic keratocyst okc was first described in 1876, named by phillipsen in 1956 and has been associated with a tendency to recur. Odontogenic keratocyst was designated as keratocystic odontogenic tumor kcot in the new world health organization classification and ooc should be distinguished from kcot for differences in histologic features and biologic behavior. There were sixty orthokeratinized cysts in fiftynine patients. Arch pathol lab medvol 4, february 2010 orthokeratinized odontogenic cyst dong et al 273 figure 2.
Oct 01, 2014 orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as okcs. The orthokeratinized odontogenic cyst ooc is a developmental. According to the new histological classification of the world health organization who, okc is considered an odontogenic tumor. The orthokeratinized odontogenic cyst ooc 1 was first clearly identified as an orthokeratinzed variant of the odontogenic keratocyst by wright in 1981 2 owing to its different histopathology and reduced likelihood to recur. Mar 01, 2017 the differential diagnosis may include orthokeratinized odontogenic cysts ooc or, when inflamed, a dentigerous cyst. The orthokeratinized odontogenic cyst ooc is a quite uncommon cyst of developmental odontogenic cyst. In 1981, wright identified it, owing to its different histology and relatively low recurrence rate, as orthokeratinized variant of odontogenic keratocyst okc. The orthokeratinized odontogenic cyst coo is a rare developmental cyst that affects the jaws, representing about 0.
Odontogenic and non odontogenic developmental cysts. Odontogenic cysts developmental dentigerous cyst odontogenic keratocyst orthokeratinized odontogenic cyst gingival alveolar cyst of the newborn gingival cyst of the adult lateral periodontal cyst calcifying odontogenic gorlin cyst glandular odontogenic cyst eruption cyst cyst lumen lining epithelium. The orthokeratinized odontogenic cyst ooc is a rare developmental odontogenic cyst that has been considered as a variant of the keratocystic odontogenic. Orthokeratinized odontogenic cyst ooc is an uncommon lesion of the jaws and represents 7%17% of all keratinizing jaw cysts. Moreover, table 3 indexes of labeled cells for metallothionein and ki67 in radicular cyst rc, dentigerous cyst dc, orthokeratinized odonto considering imt in the suprabasal layer, a signi. Although both the first two editions of the world health organizations who histological classification of odontogenic tumours recognized that cases with. Orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst characterised by a lining of orthokeratinized stratified squamous. Schultz in 1927 was the first to describe it as an orthokeratinized variant of okc and further wright in 1981 termed it as orthokeratinized variant of okc, and defines it as an independent clinical entity. However, the odontogenic keratocyst exhibits a palisaded basal layer of cuboidal to.
May 22, 2019 orthokeratinized odontogenic cysts ooc are developmental odontogenic cysts characterised by an orthokeratinized stratified squamous epithelial lining. Pdf orthokeratinized odontogenic cyst of the maxilla. The histopathological examination revealed an orthokeratinized odontogenic cyst. Apr 16, 2014 the purpose of this report is to document the clinical, radiographic, pathological and molecular findings of the first case of multiple orthokeratinized odontogenic cysts oocs. Who histological classification of odontogenic and. Odontogenic keratocyst okc and orthokeratinized odontogenic cyst ooc show considerable difference in biological behavior, and the study of the organization of collagen fibers may be helpful in understanding the nature of these variants. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously designated as odontogenic keratocysts okcs. Carvalho ch1, aquino ar, nonaka cf, silva js, germano ada r, pinto lp.
Evaluation of biological behavior of odontogenic keratocyst. Orthokeratinized odontogenic cyst a clinicopathologic study of 61 cases qing dong, mds. The purpose of this study is to determine the clinicopathological features and to. It is a solitary lesion that mostly occurs in the mandible rather than the maxilla. The term odontogenic keratocyst okc was later used by philipsen in 1956 to define all cysts with keratin formation. Orthokeratinized odontogenic cysts presenting as a periapical lesion. The orthokeratinized odontogenic cyst ooc was first identified by wright in 1981 as an individual entity distinct from other odontogenic cysts 1. Orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of keratocystic odontogenic tumor kcot. This concept, independent of odontogenic developmental cyst, has been inherited by the who classification of head and neck tumours who 2, because of the many single cystic cases. Apr 01, 2014 in 1992, world health organization who 1992 has defined orthokeratinized odontogenic cyst ooc as the uncommon orthokeratinized type of odontogenic keratocyst okc. An odontogenic cyst is a pathological, epitheliallined cavity containing fluid or semifluid which arises from the epithelial remnants of tooth formation. The designation ooc refers only to an odontogenic cyst that microscopically has an orthokeratinized epithelial lining. Oocs were first described in 1927 by schultz 2asa variant of odontogenic keratocysts, now known as keratocystic odontogenic tumours kcots 3. Surgical treatment of orthokeratinized odontogenic cyst in.
The most important lesion to distinguish from the orthokeratinized odontogenic cyst is the true odontogenic keratocyst. Orthokeratinized odontogenic cyst with calcification. Several studies subsequently discussed the true nature and the histopathological classification of oocs 2,3. Orthokeratinised odontogenic cyst ooc denotes the odontogenic cyst that. Oocs were first described in 1927 by schultz as a variant of odontogenic keratocysts, now known as keratocystic odontogenic tumours kcots.
Metallothionein in the radicular, dentigerous, orthokeratinized odontogenic cysts and in keratocystic odontogenic tumor. A rare case report of orthokeratinized odontogenic keratocyst. The 1992 world health organization who classification of odontogenic cysts is widely recognized and categorizes them as developmental or inflammatory in nature. A case of orthokeratinized odontogenic cyst suspected to be a radicular cyst. Figure 4 histopathology of orthokeratinized odontogenic cyst show ing a cystic cavity lined by squamous epithelium with a large layer of orthokeratin in all its extension haematoxylin and eosin, original magni. Pdf orthokeratinized odontogenic cyst ooc is a developmental cyst of odontogenic origin and was initially defined as the uncommon. They are rare, making up approximatel%ogenic cysts and they usually. In case 2, a 23yearold woman presented a radiolucent lesion surrounded by radiopaque halo bilateral dentigerous cyst dc was rended. They are rare, making up approximately 1% of all odontogenic cysts and they usually occur singly. Orthokeratinized odontogenic cyst ooc is a relatively uncommon developmental cyst of the jaw constituting about 10%. Orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness 1. Out of the two variants, the parakeratinized variant is thought to have a high recurrence rate than the orthokeratinized. A case report of orthokeratinized odontogenic cyst with sebaceous differentiation in a 24yearold male patient is. The orthokeratinized odontogenic cyst may share some histologic.
Jul, 2018 orthokeratinized odontogenic cyst ooc is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness. Odontogenic keratocyst okc is an aggressive cyst and its recurrence is higher than other odontogenic cysts, orthokeratinized odontogenic cyst ooc is a cyst with moderate biological behavior in. Apr 04, 2019 orthokeratinized odontogenic cyst ooc is a rare, developmental odontogenic cyst which was considered in the past to be a variant of keratocystic odontogenic tumor kcot. Orthokeratinized odontogenic cyst in a hong kong community.
The orthokeratinized cyst shows little clinical aggressiveness. Orthokeratinized odontogenic cyst masquerading as dentigerous. Of note, a dentigerous cyst is, by definition, always associated with an unerupted tooth. Nine cases of radicular cyst rc, nine dentigerous cyst dc, four orthokeratinized odontogenic cyst ooc, and eight kot were submitted to immunohistochemistry using anti. It comprises about 10% of cases that had been previously called as odontogenic keratocysts. Orthokeratinized odontogenic cysts oocs are relatively uncommon developmental cysts lined with orthokeratinized epithelium consisting of a prominent granular layer and a basal layer of low cuboidal flattened cells that show no tendency for nuclear palisading. Multiple odontogenic keratocysts are one of the major features of nevoid basal cell carcinoma syndrome nbccs, and loss of heterozygosity in the ptch gene, the culprit gene for nbccs, has recently been found in. Surgical treatment of orthokeratinized odontogenic cyst in maxillary. Although both the first two editions of the world health organizations who histological classification of odontogenic tumours recognized that cases. The orthokeratinized odontogenic cyst ooc1 was first clearly identified as a distinct entity by wright in 1981. Orthokeratinized odontogenic cyst ooc clinicopathological and radiological features of a series of 10 cases. The orthokeratinized odontogenic cyst ooc is an uncommon developmental cyst that occurs between the sec ond to.
Pitfalls on frozen section include sampling errors, insufficient epithelium, and inflammation, which may result in added challenges. Lateral periodontal cyst and botryoid odontogenic cyst. On rare occasions, focal sebaceous glands may be found in orthokeratinized odontogenic cysts see fig. Jun 01, 1981 clinical results orthokeratinized odontogenic cysts represented per cent of all cysts coded as odontogenic keratocysts at this institution. Dentigerous cyst 82 36 118 glandular odontogenic cyst 2 3 5 residual cyst 27 4 31 orthokeratinized cyst 4 3 7 gingival cyst 0 1 1 eruption cyst 1 0 1 paradental cyst 5 0 5 total 271 193 464 gender was not specified in 6 cases. Recognition of ooc as a unique entity is of utmost importance as it bears.
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